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The detrimental effects of loneliness on health

The detrimental effects of loneliness on health are becoming increasingly evident as researchers uncover the intricate mechanisms that link lack of social interaction to a higher risk of cardiovascular disease and dementia. Loneliness is a complex concept, encompassing both social isolation and the subjective feeling of dissatisfaction in one’s social relationships. According to Andrew Sommerlad, an old-age psychiatrist at University College London, loneliness can manifest as a deeply personal experience of feeling disconnected from meaningful social bonds.

This sense of loneliness has been associated with a long list of health conditions, ranging from depression to an increased risk of suicide. It may not come as a surprise that lonely individuals are more likely to experience high blood pressure and immune-system dysfunction compared to those who do not feel lonely. Furthermore, startling connections have been made between loneliness and dementia, with studies suggesting that lonely individuals are significantly more likely to develop neurodegenerative conditions.

The physiological effects of loneliness, such as disrupted sleep patterns and increased stress-hormone levels, contribute to a weakened immune system and heightened vulnerability to infections. Cognitive neuroscientist Livia Tomova of Cardiff University warns that unraveling the exact causal relationship between loneliness and health problems is challenging due to the complex interplay of various factors. However, it is evident that loneliness has a more pronounced effect on individuals belonging to disadvantaged groups.

Recent surveys conducted by Cigna Group, a US health-care insurance company, have revealed that Black and Hispanic adults, as well as individuals earning less than $50,000 per year, report higher rates of loneliness compared to other demographic groups. The emotional distress caused by loneliness can be particularly difficult to cope with for those who lack the financial resources to adapt their social situations. The COVID-19 pandemic has further exacerbated feelings of loneliness by forcing individuals to isolate for extended periods, leading to increased social disconnection.

Although older adults have traditionally been viewed as the demographic most affected by loneliness, recent data suggests that young adults are also experiencing high levels of loneliness. Research is shedding light on how the brain functions differently in response to loneliness, with studies indicating that lonely individuals perceive the world in a distinct manner compared to non-lonely individuals. Loneliness can create a negative cycle where individuals interpret social interactions negatively, reinforcing their feelings of isolation.

Furthermore, loneliness has been found to impact brain processes related to reward and motivation. In studies involving mice, researchers observed that loneliness sensitized neurons associated with the neurotransmitter dopamine, leading to heightened sensitivity to rewards. This underlying mechanism suggests that lonely individuals may be more predisposed to seeking rewards to alleviate their sense of isolation.

Chronic loneliness has been linked to increased levels of stress hormones called glucocorticoids, which can have detrimental effects on cognitive function and overall brain health. Persistently high levels of glucocorticoids have been associated with neurodegenerative conditions such as dementia, highlighting the long-term consequences of loneliness on brain health. Additionally, research has shown that lonely individuals may experience changes in brain connectivity, particularly in regions linked to social interactions and memory.

Interventions to address loneliness include increasing access to social activities and promoting community engagement. Physical exercise has also been shown to have positive effects on combating feelings of low mood associated with loneliness. Studies have demonstrated that activities like walking can not only improve mood but also enhance overall well-being by stimulating neural pathways that counteract rumination and negative self-reflection.

In conclusion, the detrimental effects of loneliness on health are multifaceted and complex, involving a range of physiological, psychological, and social factors. By understanding the underlying mechanisms that link loneliness to adverse health outcomes, researchers and healthcare professionals can develop more targeted interventions to combat the negative impacts of social isolation. Loneliness is not just a personal experience but a public health concern that requires collective efforts to address and alleviate its effects on individuals and society as a whole.

Source: https://www.nature.com/articles/d41586-024-00900-4